Sr. Downstream Processing Technician

Downstream Processing Technician

Job Description

Join our team as a Downstream Processing Technician, where you will play a crucial role in supporting the manufacture of commercial and clinical biologics. You will adhere to Current Good Manufacturing Practices (cGMPs) and be involved in various downstream processes such as purification and filtration, including HPLC. This role requires hands-on experience with large-scale production bioreactors, chromatography, and the preparation of buffers and bulk reagents.

Responsibilities

• Review all area documents to ensure accuracy and compliance.

• Assist in the manufacture of controls and calibrators, completing batch records per cGMPs.

• Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.

• Weigh, transfer, and mix chemicals as required.

• Perform product filtrations and maintain clean and sterile conditions.

• Clean and steam steel tanks (CIP/SIP) and prepare equipment for sterilization.

• Maintain and troubleshoot lab equipment including pumps and flow meters.

• Keep department lead or manager informed of any issues.

• Monitor and manage stocks of common lab supplies.

• Respond to emergency notifications and perform other job duties as required.

• Be available for flexible hours, including weekends.

Essential Skills

• Bachelor's Degree in Science (STEM-related field).

• Minimum of 2 years of work experience in manufacturing, operation, production, or lab setting.

• Proficiency in aseptic techniques and chemical concepts.

• Experience working in a cGMP regulated environment is preferred.

Additional Skills & Qualifications

• 6 months of experience in a GMP regulated environment and aseptic technique preferred.

• Subject Matter Expert on downstream processing steps is a plus.

• Experience with chromatography and HPLC is beneficial.

Work Environment

Work will be conducted in cleanroom/asceptic suites where adherence to gowning procedures is mandatory. The role involves a rotating 12-hour day shift schedule, working 7 days out of a 2-week period. Physical demands include standing for 80% of the shift and the ability to lift a minimum of 25 lbs independently. Gowning requirements include wearing a full suit, gloves, hair and beard nets, and safety glasses. The use of makeup, jewelry, nail polish, and scented products is prohibited.

Job Type & Location

This is a Contract to Hire position based out of Saint Louis, Missouri.

Pay and Benefits

The pay range for this position is $27.00 - $28.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on Sep 17, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email (% ) for other accommodation options.