Scientist, Protein Production and Screening

Scientist, Protein Production and Screening

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space.

The US Structural Biology Center of Excellence (CoE) at GSK, a new joint Vaccines and Pharma Center, will be established in Cambridge, MA in 2025. The mission of the CoE is to apply the full range of structural biology, protein biochemistry, and computational tools to design vaccine antigens, RNAs, delivery systems, and formulations for vaccines as well as to design antibodies, biologics, and small molecules.

We're looking for a passionate and highly motivated scientist to join the CoE. As a crucial member of our team you will deploy your scientific knowledge in recombinant protein production from mammalian, bacterial and/or insect expression systems. We are eager to see your contributions to our candidate screening platform to increase throughput and improve the depth of data available. The position will require active collaboration with diverse team to work together and address key challenges.

You will be expected to maintain our laboratory environment and introduce new methods/protocols related to your specific area of expertise. Your time-management and organization skills will be highly valued. This position offers you the opportunity to actively contribute to multiple pipeline projects simultaneously and directly impact the progression of our preclinical medicine and vaccine candidates. You will need to anticipate problems, proactively seek solutions, and balance competing priorities to be successful. This role interacts directly with both upstream and downstream counterparts to enable smooth communication and hand-off of materials. You will also have the opportunity to interact with scientists based in other centers and countries, ensuring that you can access the most up-to-date knowledge and capabilities to efficiently fulfill your missions.

Key Responsibilities:

• Propose, implement, maintain, and deliver existing and/or new capabilities for the high-throughput, small-scale recombinant protein production.
• Propose and implement lab automation solutions to enable rapid screening and data presentation to drive project decisions.
• Collaborate with the protein expression, protein purification, molecular design, biophysics, and structural biology teams to ensure the correct prioritization of samples.
• Deliver high quality data with appropriate control experiments and documentation
• Interpret the results of experiments and update protocols accordingly.
• Keep current with the latest developments and techniques in the field.
• Ensuring safety procedures and regulations are followed in the laboratory.
• Present research findings and updates in internal reports, project meetings, and external scientific meetings when appropriate.

Basic Qualifications:

• BSc (with 6+ years of experience), MSc (with 4+ years of experience), or PhD. (with 0+ years of experience) in protein biochemistry, cell biology, biology, molecular biology or related field.
• Two or more years of experience, preferably in an industrial research environment, national lab and/or other protein production core facility.
• One or more years of experience utilizing lab automation techniques including small scale protein expression, small scale protein purification, analytical techniques in 96 and/384 well plates.
• One or more years of experience purifying protein from mammalian cell culture including HEK293 and/or CHO cell lines.
• One or more years of experience in the operation and maintenance of AKTA systems.

Preferred Qualifications:

• PhD in protein biochemistry, cell biology, biology, molecular biology or related field
• Hands-on experience with a lab automation solution, i.e. Tecan, Hamilton, and/or Echo

• Experience with the purification of proteins from additional protein expression systems including bacterial, insect and/or yeast.
• Familiarity with buffer exchange, TFF, and related process techniques.
• Ability to further characterize purified material for endotoxin contamination and/or bioburden.
• Ability to further characterization purified material using biophysical techniques including HPLC, nanoDSF, BLI, SPR and/or mass photometry.

• Excellent oral and written communication skills with a fluency in English.

• Able to efficiently manage uncertainty, changes in priority and timeline restrictions.
• Excellent problem-solving skills and the ability to troubleshoot technical issues.
• Demonstrated ability to work independently and as part of a diverse team.
• Demonstrated ability to manage competing priorities and stakeholders.
• Strong communication skills.

#Vx-Cam

#Li-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/