Scientist or Senior Scientist I, Antibody Oligonucleotide Conjugation (AOC)

Job Title

AbbVie is seeking an innovative scientist to join our Discovery Research team, specializing in pre-clinical research and development of antibody oligonucleotide conjugates (AOCs), as well as antibody drug conjugates (ADCs).

Key Responsibilities:

• Synthesis, purification, and characterization of AOCs and ADCs on mg to gram scale under minimal supervision.
• Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.
• Optimization and validation of formulation buffers for AOCs and related bioconjugates.
• Application and refinement of automated techniques for AOC/ADC synthesis and purification.
• Collaboration with cross-functional teams to advance AOC discovery programs from conceptualization to early development.

Qualifications:

• B.S. degree with typically 5-10+, M.S. degree with typically 2-8+, or PhD with typically 0+ years of experience in Analytical Chemistry, Biochemistry, Molecular Biology, or related field.
• Demonstrated hands-on expertise in laboratory-scale protein purification using Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed-mode chromatography, and/or affinity chromatography. Experience with GE AKTA FPLC and Unicorn software is preferred.
• Strong experience in the discovery, design, synthesis, and purification of Antibody Oligonucleotide Conjugates (AOC), including familiarity with associated chemistries and analytical methods.
• Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis techniques (e.g., CE-SDS, icIEF).
• Proven problem-solving skills, motivation, enthusiasm, attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment.
• Superior written and oral communication skills, with a strong record of collaboration and innovation.

Preferred:

• Previous experience with linker chemistry and payload conjugation strategies specific to oligonucleotide therapeutics.
• Experience troubleshooting or optimizing the stability and delivery of antibody-oligonucleotide conjugates.

Position will be filled at level commensurate with extent of education, experience, and accomplishment Scientist I, Scientist II, or Senior Scientist I.

The compensation range described below is the range of possible base pay compensation that the company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.