Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology

Principal Scientist Within Oncology Discovery Pharmacology And In Vivo Biology

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Responsibilities

In the role as Principal Scientist within Oncology Discovery Pharmacology and In Vivo Biology, the ideal candidate will:

• Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects.
• Demonstrate critical thinking to address project challenges and independently drive the program forward with solution-oriented mindset.
• Characterize drug candidates in vivo as part of the lead selection process, utilizing strong foundational knowledge of building PK, PD, BioD and efficacy relationship in vivo and employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND.
• Identify and develop state of the art in vivo models, experimental protocols and relevant assays. Work with cross-functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings.
• Design, independently execute and deliver experiments with comprehensive high quality data sets to drive decision making. Interpret results of complex experiments. Use relevant information, technology and resources, contributing to complex team problem resolution and goals. Proactively foster relationships across disciplines to facilitate decision making process.
• Participates in the decision-making process for completion of team goals and communicates program strategy and timelines to Project teams. Prepare and present comprehensive technical or project updates in team meetings and other forums.
• Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy. Encourages use of experimental / innovative approaches within group.

Experience

Basic Qualifications:

• Bachelor's Degree
• 8+ years of academic and / or industry experience

Or

• Master's Degree
• 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
• 4+ years of academic and / or industry experience

Preferred Qualifications:

• PhD immunology, cancer biology or relevant biological science with 4+ years of relevant industry experience in in vivo pharmacology and a comprehensive expertise in oncology drug discovery, T cell biology and immuno-oncology.
• Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic.
• Demonstrated ability to independently develop focused in vivo strategies and utilizing PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers is required.
• Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research is required.
• Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development is highly desired.
• Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex and immune profiling by flow cytometry. Proficient in developing FACS panels, executing ex-vivo profiling approaches and analyzing FACS datasets.
• Familiar with PET/CT, IVIS and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities.
• Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues are required.
• Competitive candidates are expected to have a strong track record of independent and innovative research.

Compensation Overview: Cambridge Crossing: $156,180 - $189,252

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable