JobsUSAScientist I/II, Biologics Cell Line Development
Company : AbbVie
Location : South San Francisco, CA, 94080
Posted Date : 15 September 2025
Job Type : Other
Category : Scientific Research & Development
Occupation : Scientist
Job Details
Scientist I Or Scientist II
The Cell Line Development Group in South San Francisco, CA is seeking a Scientist I or Scientist II to join a talented and collaborative team developing CHO cell lines for GMP applications. In this laboratory position the candidate will perform hands-on CHO cell line development and characterization studies in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. The work will encompass cellular and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our pipeline candidates.
Responsibilities include:
- Performing CHO cell line development, including transfection, selection, single cell subcloning, growth and productivity screening, cell banking and stability assessment of cell banks.
- Culturing mammalian cells across multiple scales and formats, from 96-well plates up to shake flasks.
- Operating instruments like ViCell automated cell counter, Octet, Clone Select Imager, microscope, HPLC, ambr15, Beacon, flow cytometer and Liquid handlers (Tecan and Hamilton). Share responsibility for equipment maintenance.
- Authoring and reviewing cell line development technical reports that meet expectations of regulatory agencies for all stages from IND to BLA.
- Presenting updates at cross-functional meetings and collaborating closely with cell culture, purification, analytical and formulation development colleagues to meet project timelines.
- Actively seeking opportunities to optimize or enhance the cell line development workflow.
- May publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia.
- Displaying effective organization, verbal and written communication skills, and adherence to good documentation practices.
Basic qualifications:
- Scientist I: Bachelor's Degree or equivalent education with typically 5 years of experience, or Master's Degree or equivalent education with typically two years of experience.
- Scientist II: BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
- Proficient in aseptic techniques and mammalian cell culture. Strong understanding of cell biology and bioprocess engineering concepts.
- Experienced in developing stably transfected CHO cell lines for production of monoclonal antibodies and antibody-like molecules.
- Experienced in operating liquid handlers like Tecan and Hamilton for automated, high throughput cell culture activities.
- Excellent attention to detail and must keep detailed records in electronic lab notebook on a daily basis.
- Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.
- Demonstrated ability to learn, understand and master new experimental techniques.
- Demonstrated ability to work collaboratively within and outside of the group.
- Demonstrated ability to author technical reports and presentations.
- Proficient with Microsoft Office software and able to learn new software applications.
- Able to multi-task and work within timelines.
- Strong communication skills verbal, written, scientific data presentation.
Preferred qualifications:
- Exposure to CHO cell line development for GMP applications within biotech/pharma industry.
- Previous hands-on experience with Beacon, flow cytometry, ddPCR and ambr15 operation.
- Prior experience in evaluating, optimizing and establishing automated, high throughput cell culture workflows using liquid handlers like Tecan and Hamilton.
- Proficiency in programming/data science languages, such as R, Python, and SQL. Prior experience performing statistical analysis and visualization using JMP, SIMCA, Spotfire and Power BI.
This is an on-site position located in AbbVie's South San Francisco location.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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