Senior Scientist - Targeted Protein Degradation

Overview

Senior Scientist - Targeted Protein Degradation at Amgen. The Targeted Protein Degradation function within IPP seeks a highly motivated Senior Scientist to support Molecular Glues discovery and to establish and execute phenotypic-based screening platforms. This dual focus role will be central to advancing Amgen's strategy in emerging induced proximity technologies and will provide the opportunity to lead from the bench while shaping platform capabilities that enable broad discovery efforts.

The role is within Amgen's Induced Proximity Platform (IPP) organization, which aims to pioneer transformative drug modalities that harness proximity biology to access previously undruggable targets and expand therapeutic possibilities across Oncology, Cardiometabolic disorders, Inflammation, and Rare diseases. The team collaborates across functions to accelerate discovery of transformative medicines for patients in need.

What you will do

Lead and contribute to molecular glue degrader discovery through the establishment and execution of phenotypic-based screening platforms. The position focuses on integrating mechanistic biology with phenotypic screening to discover novel therapeutic opportunities and advance Amgen’s strategy in induced proximity technologies. You will work with cross-functional teams across IPP and partner functions to broaden understanding of IPP technologies and their practical applications.

Key responsibilities include:

• Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
• Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
• Collaborate with automation and high-throughput screening teams to scale phenotypic platforms for broader IPP application.
• Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
• Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
• Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
• Share insights through internal presentations, publications, and external conferences.
• Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications.

Basic Qualifications

Doctorate degree (PhD OR PharmD OR MD) (and relevant post-doc where applicable) OR Masters degree with 3 years of directly related experience OR Bachelors degree with 5 years of directly related experience.

Preferred Qualifications

• PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
• 2+ years of relevant industry experience (biotechnology or pharmaceutical research).
• Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
• Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
• Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
• Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
• Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
• Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
• Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we will support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save toward retirement or other goals, work/life balance, and career development opportunities. Benefits include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

Equal Opportunity Employer information and accommodation statements follow as part of our legal and policy disclosures.

Seniority level

Mid-Senior level

Employment type

Full-time

Job function

Research, Analyst, and Information Technology

Industries

Biotech / Pharmaceutical research