Senior Scientist II, Immunosafety/Immunogenicity

Job Title

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio.

Job Description

Purpose

This role will be responsible for evaluating immunogenic risk potential in vitro of candidate therapeutic large molecules and develop novel in vitro immunosafety assays to support development of preclinical molecules.

Key Responsibilities

• Execution of in vitro immunogenicity and immunosafety platform for risk assessment.
• Implement expansion of immunogenicity platform through MHC-II associated peptide proteomics (MAPPs) and real-time DC internalization assay development for large molecules using human DC/PBMC models.
• Represent IVIS team on project meetings, designing & coordinating IVIS studies of biologic drug candidates.
• Author publication, presentations, and/or regulatory documents.

Qualifications

• Bachelor's Degree and typically 12 years of experience OR Master's Degree and typically 10 years of experience OR PhD and typically 4 years of experience.
• Ph.D. in Biological Sciences, Cellular Immunology, preferred.
• Understanding of cellular immunology with an emphasis on dendritic and T cell biology.
• Experience with multicolor flow cytometry panel design, BD LSRFortessa instrument operation, BD FACSDive and FlowJo software, and flow cytometry data analysis.
• Proven track record with assay development experience successfully handling human samples, isolating cell subsets, maturing antigen presenting cells, and executing proliferation assays.
• Experience with in-silico immunogenicity assessment platforms a plus.
• Excellent interpersonal and oral/written communication skills.
• Results-oriented work ethic and a positive "can-do" attitude with a strong sense of urgency and self-motivated desire to achieve common business goals.
• Team player with the capability to collaborate effectively in a dynamic, cross-functional matrix environment.
• Adaptability to rapid changes in project priorities and timelines.

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

This job is eligible to participate in our long-term incentive programs

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.