Senior Scientist: Data Analytics and Pharmacometric Modeling

Senior Scientist: Data Analytics and Pharmacometric Modeling

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Overview: The Senior Scientist focuses on data science, pharmacometric modeling, and quantitative systems pharmacology to support drug development across therapeutic areas within Amgen's Clinical Pharmacology, Modeling and Simulation (CPMS) department.

What You Will Do

1. Designs modeling and simulation and analytics components of clinical drug development plans and provides expertise to project teams, including planning, design, implementation and oversight of M&S plans for multiple programs in Amgen portfolio.
2. Plan analyses to integrate pharmacokinetics, pharmacodynamics, patient characteristics and disease states to optimize doses, dosage regimens and study designs.
3. Contribute to analysis of in-vitro and pre-clinical PK/PD data for selection of first in humans (FIH) dose levels and to IND submissions and documentation of reports.
4. Make recommendations for clinical doses and dosing algorithms (including drug interaction advice, food effects, special population dosing, etc.) to clinical and development teams and in regulatory documentation.
5. Influence external environment through publications and presentations.
6. Communicate with partners (e.g., clinical pharmacologists, clinical assay group, statistics) to ensure appropriate support for programs and studies.
7. Provide leadership, guidance and advice in own field, and develop innovative output based on interpretation and analysis.

Basic Qualifications

• Doctorate degree (PhD) OR PharmD OR MD (and relevant post-doc where applicable)
• Or Master’s degree and 3 years of relevant experience
• Or Bachelor’s degree and 5 years of relevant experience

Preferred Qualifications

• PhD in Statistical and Data sciences, Computer Science, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees (e.g., MD, PharmD)
• 3+ years of experience in life sciences/biotech/pharma industry, consulting, or post-doctoral training
• Experience with scripting and implementing data analytics algorithms and models; hands-on experience with modeling and simulation software (e.g., Python, Matlab, R, NONMEM, SAS)
• Knowledge of machine learning/AI tools in life sciences and handling related datasets
• Experience in PK/PD modeling and population-based analyses/simulations with model-based drug development across multiple therapeutic areas
• Excellent interpersonal, technical, and communication skills to lead cross-functional teams
• Record of scientific contributions through peer-reviewed articles and external presentations

What You Can Expect From Us

Amgen provides opportunities for professional and personal growth and well-being, with competitive benefits and a collaborative culture. Salary is posted as a range and may vary based on skills, experience, and qualifications.

We offer a Total Rewards Plan including health and welfare plans, savings and retirement plans, work/life balance, and career development opportunities where eligible.

Equal Opportunity

Amgen is an Equal Opportunity employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We provide reasonable accommodation to participate in the job application or interview process where needed. Applicants may redact age-identifying information in materials submitted.