Scientist - Targeted Protein Degradation - Thousand Oaks, CA

Scientist - Targeted Protein Degradation - Thousand Oaks, CA

Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please follow the next steps.

Amgen's Induced Proximity Platform (IPP) organization is committed to pushing the boundaries of drug discovery by harnessing proximity biology to address difficult and previously undruggable targets. The IPP team develops novel therapeutic modalities, including Molecular Glue Degraders and other Induced Proximity strategies, with applications across Oncology, Cardiometabolic Disorders, Inflammation, and Rare Diseases. Our scientists are part of a collaborative, multidisciplinary environment where biology, chemistry, and technology innovation converge to deliver transformative medicines for patients.

The Targeted Protein Degradation function within IPP is seeking a motivated Scientist to play a key role in building phenotypic-based screening platforms that will enable the identification of Molecular Glues for high-value targets. In this vital role you will contribute directly to cutting-edge drug discovery programs, while developing valuable expertise at the intersection of molecular biology, cell biology, and chemical biology.

Key Responsibilities:

• Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets.
• Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action.
• Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs.
• Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery.
• Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, Cell viability assays).
• Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams.
• Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts.
• Present research progress in team meetings and contribute to technical reports and publications.
• Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork.

Basic Qualifications:

• Doctorate degree
• Or Master's degree and 2 years of directly related experience
• Or Bachelor's degree and 4 years of directly related experience

Preferred Qualifications:

• Master's degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field.
• 1+ years of relevant industry experience (biotechnology or pharmaceutical research).
• Hands-on experience with cellular and molecular biology techniques (e.g., cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods).
• Experience in cell-based assay development and/or phenotypic screening approaches.
• Familiarity with protein degradation or induced proximity biology.
• Exposure to automation or high-throughput technologies.
• Strong data analysis skills, with the ability to interpret, and efficiently report, experimental results and troubleshoot assays.
• Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment.

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible. Salary Range $119,462.00 USD - $141,618.00 USD