Research Scientist II/III, DNA Synthesis

Overview

Research Scientist II/III, DNA Synthesis – Redmond, WA. This role focuses on oligonucleotide synthesis, surface functionalization, and molecular biology to advance proprietary semiconductor DNA synthesis technology and diagnostic applications.

Responsibilities

• Develop and synthesize desired organic compounds.
• Select and employ analytical techniques for synthesized compounds.
• Develop and perform on-machine oligo synthesis with various modifications.
• Develop surface functionalization for metal and non-metal surfaces for solid-phase oligonucleotide synthesis.
• Select and employ analytical techniques for surface characterization.
• Explore methods to enhance surface stability and functional loading.
• Contribute knowledge in nucleic acid chemistry, specifically phosphoramidite-based oligonucleotide synthesis.
• Transfer technology to the production team and support process improvement or troubleshooting.
• Perform statistical data analysis and present the results.

Qualifications

• Ph.D. in Organic Chemistry, Biochemistry, Chemical Biology, or a related field; or MS with at least 3 years of relevant industry experience.
• Expertise in nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
• Strong foundation in organic chemistry and photochemistry.
• In-depth understanding of nucleic acid chemistry and phosphoramidite-based synthesis.
• Hands-on experience with total synthesis and purification techniques (column chromatography, HPLC, Biotage).
• Proficiency in handling sensitive materials (preferred).
• Familiarity with laboratory automation tools (a plus).
• Advanced molecular biology skills, including PCR, qPCR, hybridization assays, and next-generation sequencing (NGS).
• Proven collaboration within interdisciplinary and cross-functional teams.
• Results-driven and proactive in experimental design and problem-solving.
• Excellent written and verbal communication skills.
• Strong documentation skills for technical reports and technology transfer to manufacturing.
• Highly self-motivated and passionate about driving innovation in biotechnology.

Benefits

• Medical, Vision, and Dental Insurance
• 401(k) & Retirement Savings Plan
• Short Term Disability Insurance
• New Child Leave
• Paid Time Off
• Paid Company Holidays
• Paid Sick Days
• Compassionate Leave
• Jury Duty Leave
• Float day
• Personal days

Perks

• Free colleague meals during shift
• Onsite massages
• Onsite gyms

Compensation

Salary range: $80,000 – $110,000, depending on experience and qualifications.

Equal Opportunity

GenScript USA Inc./ProBio Inc. is an equal opportunity/affirmative action employer committed to diversity and inclusion. It is the Company's policy to provide equal employment opportunity without discrimination or harassment based on race, color, religion, sex, pregnancy, childbirth or related medical conditions, sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, veteran status, or any other characteristic protected by law. It maintains a drug-free workplace. Please note: GenScript/ProBio will only contact candidates through verified application sources and does not request personal information via email or other platforms.