Research Scientist, Discovery Toxicology

Research Scientist

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

We are seeking an experienced Research Scientist who will work in a dynamic, multidisciplinary matrixed team within our Lawrenceville, N.J. Discovery Toxicology organization to generate and interpret data from in vitro and in vivo studies supporting nonclinical safety assessment. The successful candidate will engage in investigative studies that support early toxicity and teratogenicity assessment using in vitro models and New Approach Methodologies (NAMs) - e.g. Zebrafish model, microphysiological systems (MPS) and organoids - and will also support in vivo studies with mechanistic investigations and pharmacodynamic assessments for programs in a wide variety of therapeutic areas. This individual will conduct experimental work, analyze data and report results of compounds in the Discovery pipeline to provide early assessment of toxicity or teratogenic liabilities, identification of pharmacodynamic or toxicity biomarkers, as well as inform on potential mechanisms of toxicity/teratogenicity. State-of-the-art cell culture and molecular biology is required, and flow cytometry, experience working with developmental model systems, and gain-/loss-of-function approaches are highly desirable. Educational and research background in toxicology, cell biology, developmental biology, or a related field is required.

Key Responsibilities:

• Evaluate toxicity and teratogenic liability assessments for early Discovery candidates including literature-based assessments, design and execution of investigative studies and reporting of these assessments.
• Apply molecular biology and flow cytometry expertise to develop and optimize assays for evaluating toxicity endpoints and Bio-/pharmacodynamic (PD) markers associated with investigative safety assessments and issue resolution.
• Apply approaches for functional assessment of drug targets or suspect off-targets such as siRNA, antisense oligonucleotides, and/or CRISPR.
• Apply expertise above with expertise in in vitro cellular and developmental model systems to conduct investigative mechanistic studies to characterize on- or off- target liabilities to support discovery programs.
• Apply multifaceted data analysis including use of specialized data analysis software for flow cytometry and gene or protein expression data.
• Study direct, execute, and report in vitro or in vivo studies evaluating toxicity or teratogenicity.
• Author internal reports and manuscripts associated with exploratory/investigative activities in scientific journals, present research work internally and at external conferences.
• Responsible for maintaining excellent documentation of laboratory procedures and recording of data in compliance with standards defined by BMS corporate notebook policies and procedures.
• Create an atmosphere of scientific excellence, collaboration, open communication, and creativity in order to maximize productivity.

Required Competencies - Knowledge, Skills, and Abilities:

• Hands-on experience with various analytical techniques such as Flow Cytometry, ELISA and PCR.
• Hands-on experience in cell culture methods including maintaining cell lines and primary cell isolation and culture.
• Advanced ability to create and completely understand, follow, interpret and apply SOPs for various in vitro assays.
• Advanced scientific writing and presentation skills including statistical analysis, data analysis and graphing, data presentation.
• Advanced problem-solving ability/mentality, technically adept and logical.
• Ability to represent the interests of the group on cross-functional teams.
• Ability to work independently in a high-paced team environment, meet deadlines, and prioritize work from multiple projects.
• Advanced ability to communicate and collaborate effectively with peers, department management and cross-functional peers.
• Strong track record in large and/or small companies, contributing to innovative efforts within the laboratory setting to achieve defined goals and support clinical development, expertise in regulated environments & with clinical/diagnostic testing procedures is required.
• Technical skills required include blood processing, tissue processing, protein analyses including ELISA and Luminex.

• Strong expertise in flow cytometry is highly desirable, including design and validation of novel multicolor panels, staining and analyzing diverse types of samples, as well as data analysis using Flowjo, FCS Express or similar, and with expertise using different types of flow cytometers and running high dimensional flow panels.

Preferred Qualifications:

• Demonstrated competency in understanding the drug Discovery and Development process with at least 3 years of Pharmaceutical and/or Biotechnology or equivalent experience.
• Experience in advanced microscopy imaging systems and software, such as confocal microscopy and/or image analysis software.
• Experienced in target deconvolution applications such as siRNA or CRISPR including molecular activities and delivery approaches such as microinjection.
• Experience in using developmental model systems including microdissection techniques and general preparation of embryos for in vitro culture as well as experience in morphological assessment of embryos for malformations.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview: Princeton - NJ - US: $107,680 - $130,480 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process