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Principal Scientist, Group Leader, Antibody Engineering

Disability Solutions

Company : Disability Solutions

Location : South San Francisco, CA, 94083

Posted Date : 5 November 2025

Job Type : Full Time

Category : Scientific Research & Development

Occupation : Scientist

Job Details

The Position

The Opportunity

We are seeking an exceptional Principal Scientist (Group Leader) to join our world-class Antibody Engineering Department, where we discover and engineer life-changing antibody drugs through pioneering science and technology. The successful candidate will lead a scientific team to enhance existing platforms and develop novel technologies to expand our pipeline of antibody-based drugs across therapeutic areas.

You will focus on these areas
  • Contribute to research at the interface between technology and biology
  • Define important therapeutic problems in collaboration with Genentech's therapeutic areas
  • Drive innovation to solve them through antibody engineering
Our new Scientist/Group Lead will help shape the future of our antibody drug capabilities and will be expected to present their research externally and publish in peer-reviewed journals. The hire will work collaboratively in a multi-disciplinary team environment to design, validate, and advance next generation biologics that address major unmet medical needs into clinical development. We are seeking highly motivated and self-driven candidates with a passion for innovation, creativity, and commitment to translational science and drug development.

Who You Are
  • PhD in a biological science, complemented by postdoctoral training or 4+ years recent equivalent antibody engineering in academia, biotechnology and/or pharma.
  • We encourage applications from candidates with extensive prior experience as well as those coming directly from exemplary postdoc careers.
  • The successful candidate will have demonstrated a sustained record of productivity and substantive scientific contributions as determined by consistent high-impact publications, patent inventorship, and/or external presentations.
  • Candidates need to be team-oriented, collegial, and have strong interpersonal and communication skills.
Preferred
  • Ideal applicants will excel in protein engineering methodologies and be well-versed in biology.
  • Experience with engineering bi- or multi-specific antibody/protein formats is preferred.
  • Experience with structure-based protein analysis is a plus.
  • Research experience with antibodies is preferred but is not essential.
Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

#LI-KC2

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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