Principal Scientist, Cardiovascular In Vivo Pharmacology

Overview

Challenging. Meaningful. Life-changing. Working at Bristol Myers Squibb offers opportunities across departments, from optimizing production lines to breakthroughs in cell therapy. It is work that aims to transform patients’ lives and the careers of those who do it, with opportunities to grow alongside high-achieving teams.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs to support employees in work and personal goals. Read more: careers.bms.com/working-with-us.

The Immunology and Cardiovascular Thematic Research Center (ICV TRC) at BMS is a fundamental Research unit delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on cutting-edge science today, leveraging BMS’s internal invention engine with expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other modalities.

Position Summary

We are seeking a cardiovascular biologist with a track record of using molecular and cellular tools and animal models to understand the effects of mutation on cardiac structure and function as well as response to intervention. The successful candidate will apply knowledge of cardiovascular physiology to identify and validate cardiac/cardiovascular targets, establish pharmacodynamic endpoints in vivo and in vitro to enable drug discovery programs, elucidate structural-functional pathophysiology, and direct ex vivo, microscopic, and/or biochemical characterization/analysis of samples. This is a lab-based role with time spent reviewing programs/targets, analyzing data, meeting with key stakeholders and leadership to present results, and serving as a team representative.

Position Responsibilities

• Perform in vivo and in vitro/ex vivo studies to define pharmacodynamic/pharmacokinetic relationships and characterize and develop models of disease relevant to programs, as well as response to treatment

• Lead studies to completion, including directing the analysis of samples internally or externally through management of CRO activities

• Evaluate programs critically and present findings and recommendations to leadership

• Identify opportunities for protocol improvement and develop new experimental protocols

• Apply technical knowledge to make experimental in-life modifications when necessary

• Document, critically review, modify experimental approaches if necessary, and present data in a timely manner

• Collaborate with cross-functional teams by providing timely and actionable study results

• Provide hands-on training and guidance to develop team members or direct reports

• May be a functional area lead for drug discovery programs independently or with leadership support

• Contribute to and author reports, abstracts, and publications

• Write protocols for IACUC approval and work with IACUC committees

Experience and Qualifications

Basic Qualifications:

• Bachelor’s Degree

  • 8+ years of academic and/or industry experience

Or

• Master’s Degree

  • 6+ years of academic and/or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 4+ years of academic and/or industry experience

Preferred Qualifications:

• Ph.D. in Physiology, Pharmacology, Biology, Biochemistry, or a related field with 4+ years of relevant industry experience. PharmD/DVM/MD may be considered with a strong track record of achievement in the basic sciences or drug discovery from hands-on contributions. Alternatively, a M.S. in a related field with 6+ years (after completion of degree) relevant industry experience.

• Strong understanding of cardiovascular physiology and modern cardiovascular methodologies.

• Hands-on experience handling rodents is necessary

• Strong understanding of echocardiography (theory, practice, and interpretation) is preferred with hands-on experience performing echocardiography in rodents strongly preferred.

• Strong understanding of cardiovascular hemodynamics is preferred with hands-on experience performing invasive hemodynamics in rodents strongly preferred.

• An understanding of the considerations for the use of animals in research, with a focus on rationale for species-specific use, can articulate and apply 3Rs principles in designing and initiating experiments

• Highly motivated and driven by achieving goals in a team environment.

• Excellent laboratory skills, prioritizing accurate and reproducible work.

• Excellent organizational and time management skills.

• Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a multidisciplinary, matrixed team environment.

#LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview

Princeton - NJ - US: $135,800 - $164,563

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include medical, pharmacy, dental and vision care; wellbeing support; 401(k); disability and life insurance; travel protection and survivor support; paid holidays, vacation, volunteer days, sick time, and flexible hours; parental, caregiver, bereavement, and military leave; family care resources and tuition reimbursement and recognition programs.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients’ lives through science,” every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us applies our talents and perspectives in a culture that promotes global participation in clinical trials, guided by our values of passion, innovation, urgency, accountability, inclusion and integrity.

On-site Protocol

BMS occupancy and work-model structure varies by role and location, including site-essential, site-by-design, field-based and remote-by-design roles. The assigned occupancy type is determined by the nature and responsibilities of the role.

Site-essential roles require 100% onsite shifts; site-by-design roles may be eligible for hybrid work with at least 50% onsite. Field-based and remote-by-design roles require the ability to travel and attend meetings as directed. BMS provides accommodations in recruitment; requests can be directed to Visit careers.bms.com/eeo-accessibility to access our Equal Employment Opportunity statement.

BMS cares about wellbeing and recommends all employees be fully vaccinated for Covid-19 and stay up to date with boosters. BMS will consider qualified applicants with arrest and conviction records, where permitted by law. If you live in or work from Los Angeles County, please visit for additional information. Data processed in relation to role applications will be treated in accordance with applicable data privacy policies and regulations.