Research Technologist - Zadeh Lab Neurologic Surgery

Research Technologist

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

We are seeking a highly motivated and detail-oriented Research Technologist to join our translational neuro-oncology research team. Our lab focuses on glioblastoma, meningiomas, and peripheral nerve sheath tumors, with a strong emphasis on tumor microenvironment biology, spatial and single-cell transcriptomics, and molecular biomarker discovery through epigenetic modifications.

The successful candidate will support ongoing projects by performing established and emerging laboratory techniques, including but not limited to:

• Methylated DNA immunoprecipitation from FFPE and frozen tumor tissues, CSF and plasma
• Molecular biology assays (PCR, RNA/DNA extraction, qPCR, bisulfite conversion)
• H&E staining, immunohistochemistry and immunofluorescence staining on FFPE and frozen tissues
• Fluorescence and brightfield microscopy, image acquisition, and analysis
• Sample preparation for spatial transcriptomics, single-cell analysis, and next-generation sequencing
• Data entry, preliminary statistical analysis, and assistance with manuscript and figure preparation
• Organization of lab inventory, reagents, and general lab maintenance

The Research Technologist will present data in lab meetings and collaborate closely with senior lab members and trainees. The candidate will be expected to work independently on routine procedures and receive mentorship for more complex tasks. Opportunities for authorship on publications are available based on contributions.

Qualifications:

• Requires bachelor's degree in biology, chemistry, other relevant science, or an associate's degree with 6 years of relevant laboratory experience. Bachelor's degree in biology, biomedical sciences, or a related field is preferred. (Master's degree or relevant research experience preferred)
• Strong preference will be given to those who have a minimum of 3 year of hands-on wet lab experience (academic or industry); associate degree with extensive relevant lab experience will also be considered
• Proficiency in molecular biology techniques PCR and qPCR preferred
• Familiarity with immunostaining, microscopy, and basic data analysis (GraphPad, ImageJ, Excel/R) preferred
• Excellent organizational skills, attention to detail, and ability to work both independently and collaboratively
• Strong communication and documentation skills

Experience with DNA methylation, digital pathology, or prior exposure to spatial transcriptomics is an asset but not required. Training will be provided.